Rhodium-catalyzed tunable oxidative cyclization toward the selective synthesis of α-pyrones and furans.
نویسندگان
چکیده
The rhodium(III)-catalyzed tunable oxidative cyclization of readily available N-tosylacrylamides and diazo compounds is presented, which offers a novel method for the selective construction of fully substituted α-pyrones and furans in a regiospecific manner by employing the acylsulfonamide group as a versatile in situ removable directing group.
منابع مشابه
Synthesis of Polycyclic Ring Systems Using Transition Metal Catalyzed Cyclizations of Diazo Alkynyl Ketones
Abstract: The rhodium(II)-catalyzed reaction of α-diazo ketones bearing tethered alkyne units represents a new and useful method for the construction of a variety of substituted cyclopentenones. The process proceeds by addition of the rhodium-stabilized carbenoid onto the acetylenic π-bond to give a vinyl carbenoid intermediate. The resulting rhodium complex undergoes a wide assortment of react...
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عنوان ژورنال:
- Chemical communications
دوره 52 8 شماره
صفحات -
تاریخ انتشار 2016